An artificial bee colony algorithm for public bike repositioning problem

Paper PresentationConference Theme: Informing transport’s future through practical researchPublic bike repositioning is crucial in public bike sharing systems due to the imbalanced distribution of public bikes. This paper models the public bike repositioning problem (PBRP) involving two non-linear objectives, which are to minimize total service duration and the duration of the longest vehicle route. It includes practical constraints such as the tolerance of demand dissatisfaction and the limitation of duration on the longest route. These objective functions and constraints make the PBRP become NP-hard, so here introduces an artificial bee colony (ABC) algorithm to solve this PBRP. Three neighbourhood operators are introduced to improve the solution search. A modified ABC is proposed to further improve the solution quality. The performance of the modified heuristic was evaluated with the network of Vélib', and compared with the original heuristic and the Genetic Algorithm. These results may therefore prove that the modified heuristic can be an alternative to solve the PBRP. The numerical studies demonstrated that the two objective functions performed differently in which the increase in fleet size may not improve the objective value. This paper will therefore discuss on the practical implications of the trade-offs and provide suggestions about similar repositioning operations.postprin

A multiple type bike repositioning problem

This paper investigates a new static bicycle repositioning problem in which multiple types of bikes are considered. Some types of bikes that are in short supply at a station can be substituted by other types, whereas some types of bikes can occupy the spaces of other types in the vehicle during repositioning. These activities provide two new strategies, substitution and occupancy, which are examined in this paper. The problem is formulated as a mixed-integer linear programming problem to minimize the total cost, which consists of the route travel cost, penalties due to unmet demand, and penalties associated with the substitution and occupancy strategies. A combined hybrid genetic algorithm is proposed to solve this problem. This solution algorithm consists of (i) a modified version of a hybrid genetic search with adaptive diversity control to determine routing decisions and (ii) a proposed greedy heuristic to determine the loading and unloading instructions at each visited station and the substitution and occupancy strategies. The results show that the proposed method can provide high-quality solutions with short computing times. Using small examples, this paper also reveals problem properties and repositioning strategies in bike sharing systems with multiple types of bikes.published_or_final_versio

Primary extraskeletal osteosarcoma of omentum majus

Extraskeletal osteosarcoma is a rare malignant soft tissue tumor. Here we present a case of a primary extraskeletal osteosarcoma arising from omentum majus in a 40-year-old Chinese woman. Ultrasonography of the pelvic cavity showed a large soft tissue mass with marked calcification. Complete surgical resection of the primary tumor was performed and the histopathological diagnosis was extraskeletal osteosarcoma of omentum majus. She was followed up without adjuvant radiotherapy and chemotherapy, and died from widespread intra-abdominal, lung and liver metastases 7 months postoperatively

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

Non-standard errors

In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence generating process (EGP). We claim that EGP variation across researchers adds uncertainty: Non-standard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for better reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants